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What a Difference a Day Makes
Season 5, episode 22

Izzie and Alex are married.
Episode Information
Airdate	May 7, 2009
Written by	Shonda Rhimes
Directed by	Rob Corn
Episode Guide
Previous	No Good at Saying Sorry (One More Chance)
Next	Here's to Future Days
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"You never know the biggest day of your life is going to be the biggest. The days you think are going to be big ones, they are never as big as you make them out to be in your head. It’s the regular days, the ones that start out normal. Those are the days that end up being the biggest. And today was the wedding. It was beautiful. Perfect. You never know the biggest day of your life is the biggest day, not until it’s happening. You don’t recognize the biggest day of your life, not until you’re right in the middle of it. The day you commit to something or someone. The day you get your heart broken. The day you meet your soul mate. The day you realize there’s not enough time because you wanna live forever. Those are the biggest days. The perfect days. You know, it was a beautiful day."

—Izzie Stevens

What a Difference a Day Makes is the twenty-second episode of the fifth season and the 100th overall episode of Grey's Anatomy.

Short SummaryEdit

The 100th episode! Meredith and Derek prepare for their wedding for later that day. Izzie starts to see Denny again, Arizona and Callie have relationship issues and Owen refuses to give up on George as a few graduation students are admitted.

Full Summary Edit

Meredith and Derek are at the church and extremely excited. At Seattle Grace, Callie wakes up and complains to Cristina that she has to pick up extra shifts in the ER since she has no money because her father cut her off. Also, she had a date with Arizona the night before at a fancy restaurant she can no longer afford and then she bailed to go to work. Cristina slept at the hospital too and is quite cranky.

In her room Izzie is extremely excited for the wedding and she and Bailey high-five. She tells Bailey she feels fine and that she must go to the wedding but Alex is concerned that her blood pressure isn't where it should be. Once they both leave the room, Izzie notices that her hair is starting to fall out. Then, Denny shows up again, causing Izzie much distress as she asks him to leave. She realises there must be another tumor in her brain.

Alex and George are assigned to the pit, but Callie tells them they can relax because there's nothing to do and that its a slow day. Soon, a phone call comes in from an ambulance carrying bloody trauma victims. The patients are a group of college students who were on their way to their graduation but were in a terrible car accident. The surgeons scramble to deal with the carnage. Hunt finds Cristina and he tells her that it was the blades of the ceiling fan above her bed that triggered his PTSD episode, as it reminded him subconsciously of the helicopter blades in Iraq. He goes to hold her hand, but she abruptly leaves. He soon joins the rest of the team in the ER. Alex's treats the valedictorian of the class, named Becca. All she ever did was study, and her life was supposed to begin today ... after she graduated from college. Cristina's patient was driving, and he asks about his girlfriend. He says she was sitting in the backseat, and when he turned around to tell her something, she was gone.

Izzie soon pages Derek and tells him about the new visions of Denny, Derek knows what it means and orders another MRI scan. Richard pages Meredith to him about a wedding present. He tells her that it is really Derek's present to her, but he has to oversee it. Meredith explains that she doesn't want any gifts, but when Richard says that the present is actually an inflamed colon, and assigns her to her first solo surgery, she smiles and agrees.

When David, George's first trauma patient dies George gives up but Owen convinces him that he can't save everyone in his line of work, and you have to move on to save the people you can, and go where you are needed. Arizona interrupts Callie's hectic day in the pit, asking what's up. They had gone to a great four-star restaurant, and it was supposed to be so romantic, but all Callie did was order a salad and bail. Too busy, Callie barely answers and runs off to yell at some paramedics instead. In her room Bailey tries to convince Izzie to stay positive as she gets her ready for the MRI, but Izzie is convinced it's another tumor. Izzie then sees that Denny is standing right behind Bailey.

Becca, Alex's patient, continues to talk. She tells him about how she should have slept with David when she had the chance, but now he's dead and she can't. Cristina's patient also starts talking. He explains that he separated from his girlfriend for some reason, and he knew that their relationship wouldn't last, even though he loves her. George starts work on another patient who is bleeding so much that there's no way to save him. After he dies, George is so disgruntled that he asks Hunt to pull him from the pit but Owen refuses. Another patient is brought in, practically cut in half, her guts literally are spilling out. She's D.O.A. and the girlfriend of Cristina's patient, who sees her. When he realizes his girlfriend is dead, he starts coding.

Richard scrubs in on Meredith's surgery which both surprises and annoys her slightly as it is supposed to be her solo-surgery. He gets very parental, commending her on things and being subtly critical here and there as well. Mark soon enters the OR to tell Meredith that she better not leave Derek because he doesn't want to have to be Derek's best man a third time. In the ER, Arizona confronts Callie again and asks to know why Callie was so tired after their date, yet she has all this energy to be working the ER. Callie says she rallied because she just loves the pit but Arizona realizes she is lying and suggests that maybe they were just having a fling and it had done its course and lots of other women are lining up for heer anyway, Callie says maybe, shocked, Arizona walks away.

Izzie, Bailey and Derek can't see anything in Izzie's brain scans, but Izzie knows that she wouldn't be seeing Denny unless there were something. Derek gets the idea to hook her brain up to a monitoring device so that if she gets another hallucination, they'll be able to pinpoint where it is. Alex's patient Becca continues to distress, so he suggests that she give him her valedictory speech since she worked so hard on it. As she does, we see all of her friends being zipped into body bags in a poignant montage.

Denny eventually appears to Izzie, and Derek finds where hallucinatory neurons are firing in her brain. The part of the brain is the other temporal lobe, and the tumor was too small to pick up on an MRI.

Bailey wants to know how they can take it out, but Derek says that there's nothing they can do. He tells Bailey that he likes Izzie and he wishes there was something he could do, after a few moments Bailey comes up with an idea. Callie sleeps peacefully but is siddenly awoken by Arizona, Callie finally confesses that her behavior was due to the fact that she is broke and can't afford fancy four-star restaurants anymore because her father cleaned out her bank account and disowned her. Arizona says that she doesn't care, and they can stay in and eat pizza. After Meredith's surgery, Richard tells her Ellis would have been very proud to watch her do her first solo surgery.

George is down on himself as all the patients he treated died and the only one who survived was the one he didn't treat. Hunt tries to pump up George's deflated ego, saying that because George treated the other five, that allowed Hunt to go and save the sixth. He says that trauma is a team sport and he's a hero too. Lexie cries as she treats the sixth patient who survived.

Meredith tells Derek excitedly about her first solo surgery, and that she is having a great wedding day. Derek asks Meredith if she wants to make the day even better. After talking with Derek Meredith finds Alex outside. He just heard that Izzie has another tumor, and he's afraid that she might die on him. Meredith shares Bailey's idea with him.

In her room Izzie asks Bailey anxiously if she can still go to the wedding because her tumor isn't going anywhere, Bailey tells her that she can but continues to wait at the door until Meredith appears. Meredith tells Izzie that the dress isn't her and that the wedding is not for her but Izzie thinks Meredith is just having pre-wedding jitters and convinces her that Derek loves her and she has to get married. Alex appears at the door and she sees him in his suit and realises that Meredith is giving the wedding to her.

At the church, Izzie is in a dress and asks Cristina to be the maid of honor for trying to save her life when she told her about the cancer. Alex in turn asks Meredith to be his best man. The wedding begins and Izzie walks down the aisle with George by her side. Izzie worries when she realises she has no vows but Alex jumps in and recites a version of Becca's valedictory speech about this being the beginning of his life, the day he becomes accountable to someone other than himself. As Izzie and Alex kiss, everyone gets teary-eyed.

Back at the hospital, Alex tucks Izzie into bed again. He takes the flowers out of her hair and some of her hair comes out with it. He assures her that she doesn't need her hair and that she would still look great without it. She should even shave it all off. After the wedding, Callie and Arizona get naked and eat pizza, Cristina takes down her ceiling fan, and Meredith and Derek lie by the fire. In bed, Izzie again has a scarf on her head. She has been talking to Denny and asks him to go now because she wants to be alone with her husband. Alex walks in and asks why she's wearing the scarf. She takes it off to reveal she is bald. Alex says My wife is so hot and Izzie smiles.

Cast Edit

Main CastEdit

Special Guest StarEdit

Jeffrey Dean Morgan as Denny Duquette

Guest StarsEdit

Co-StarringEdit

Robin Gwynne as Becca's Mom
Trent Gill as David
Mark Saul as Intern Steve
Molly Kidder as Intern Megan
Candice Afia as Intern Laura
Mickey Maxwell as Minister
Amrapali Ambegaokar as Intern Dani
Tymberlee Chanel as Intern Claire
Winston Story as Intern Leo
Joseph Williamson as Intern Pierce
Payton Silver as Dr. Knox
Wayne Lopez as Paramedic #1
Shi Ne Nielson as Paramedic #2
Mac Brandt as Paramedic #3
Tim Chiou as Paramedic #4

Medical NotesEdit

Music Edit

Song	Performer	Scene
"First In Line"	Matthew Mayfield
"Another Likely Story"	Au Revoir Simone
"Turn to Stone"	Ingrid Michaelson

Notes and TriviaEdit

This episode's title originated from the song What a Difference a Day Makes, originally sung by Dinah Washington.
This episode scored 15.33 million viewers.
This is the 100th episode.

Gallery Edit

Episode StillsEdit

Quotes Edit

Meredith: Just a normal day.

Derek: Normal day. Going to work.

Meredith: Just a normal day, that ends in a ceremony in a churchy church.

Derek: This has nothing to do with us, we're just the bride and groom.

Callie: No! We are closed to trauma! Because we have trauma coming out of our butts! Oh, well have a nice day to you too! [sees Arizona] Oh, for the love of...

Arizona: So the ER is fun, but I'm not. You can get enough of me? Is that what you are saying? I mean, do you just want to just end this? Because there are women that are lining up for me. I'm hot.

Minister: Dearly beloved. We are gathered here today to celebrate the wedding of Alexander Michael Karev and Isobel Katherine Stevens. This is a sacred right. An ancient right. As Isobel and Alex prepare to join their lives, it is important to understand that everyone present has played a part in shaping their lives. And, will continue to play a vital role in their continuing future. And thus, we are here not only to witness their vows to each other, but to bestow upon them our blessing. And, now the couple will read their vows.

Izzie: Oh, we didn't write anything.

Alex: No, wait. I have something I wanna say. Today's the day my life begins. All my life I've been just me. Just a smart mouth kid. Today I become a man. Today I become a husband. Today I become accountable to someone other than myself. Today I become accountable to you. To our future. To all the possibilities that a marriage has to offer. Together, no matter what happens, I'll be ready. For anything. For everything. To take on life, to take on love. To take on possibility and responsibility. Today Izzie Stevens, our life together begins. And I for one can't wait.

Izzie: I love you. (kisses him)

Minister: Ahem, not yet!

Alex: Hurry up!

Minister: By the power vested in me, by god and the state of Washington, I now pronounce you husband and wife.

Izzie: Now?

Minister: Now.

(Izzie and Alex kiss.)


Grey's Anatomy Season 5
#01	"Dream a Little Dream of Me, Part 1"	#09	"In the Midnight Hour"	#17	"I Will Follow You Into the Dark"
#02	"Dream a Little Dream of Me, Part 2"	#10	"All By Myself"	#18	"Stand By Me"
#03	"Here Comes the Flood"	#11	"Wish You Were Here"	#19	"Elevator Love Letter"
#04	"Brave New World"	#12	"Sympathy for the Devil"	#20	"Sweet Surrender"
#05	"There's No 'I' in Team"	#13	"Stairway to Heaven"	#21	"No Good at Saying Sorry (One More Chance)"
#06	"Life During Wartime"	#14	"Beat Your Heart Out"	#22	"What a Difference a Day Makes"
#07	"Rise Up”"	#15	"Before and After"	#23	"Here's to Future Days"
#08	"These Ties That Bind"	#16	"An Honest Mistake"	#24	"Now or Never"
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