On September 12, 2017, it was announced that Jason George's character, Ben Warren, would be moving to the new series.
A 30-second ad during an episode of the season cost advertisers $107,272.
Before the name Station 19 was decided, the crew jokingly referred to it as Blaze Anatomy.
Some of the cast had a two-day training session with the technical advisors of the show, who are actual firefighters. They also talked with firefighters from Seattle and Los Angeles.
This first season has the largest episode number of all first seasons of the three shows from the Grey's Anatomy Universe. Both Grey's Anatomy and Private Practice only had nine episodes each for their first seasons.
This is the first season of any series of the Grey's Anatomy universe in which Jason George appears in every episode as Ben Warren.