Andrew DeLuca is beaten up by Alex Karev, who believed Andrew was attempting to have sex with Jo Wilson while she was drunk, thus raping her. Andrew pushes to have Alex charged with a felony. Meredith and Bailey try to balance their protective feelings for Alex and doing the right thing.
Meredith tries to hide the attraction between her and Riggs from Maggie, who's in love with Nathan and wishes to go out with him.
Owen and Amelia adjust to married life. They try to have a baby, but after mistakenly believing she's pregnant, Amelia realizes she's not ready to get pregnant again. Telling Owen results in a fight, leading to Amelia leaving him with a note and staying with Stephanie for a while.
April and Jackson adjust to life with their new baby as single parents.
Leah Murphy returns to the hospital to learn from Maggie after she got better at another hospital.
Her return and other rehired residents from the past make Catherine and Bailey hire Eliza Minnick to re-evaluate the residency program. In doing so, they step on Webber's toes since they neglected to tell him about Eliza's arrival. Furious about the way he was treated, Webber gains the support of the other attendings who stand up for him against Eliza.
With Callie and Sofia in New York, Arizona gets caught between her former student Alex and her roommate Andrew, both of whom she feels for. She flirts with Eliza, though does not condone her treatment of Webber or her arrogant attitude. When working together, Arizona discovers her good side and the two end up kissing.
Caterina Scorsone was pregnant with her second child during the start of filming the season. Her pregnancy was not written into the show.
Camilla Luddington was pregnant with her first child during the filming of this season. It is currently unknown if her pregnancy will be written into the show.
Ellen Pompeo welcomed a third child into her family whilst filming this season.
For production reasons, presumably including three actresses with a baby on the way, it was decided at the beginning of the season that there would be four stand-alone episodes, focusing on only a couple of characters per episode. They were all filmed around the same time in late 2016, but spread throughout the season: