Monopoly is a famous board game.
After discovering that her misguided interns cut Denny Duquette's LVAD wire, Bailey gave them orders to not speak and said, "Do not pass go!" (an reference to Monopoly) when she sent George to get his labs. ("Deterioration of the Fight or Flight Response")
Eric Sanborn was in the hospital after swallowing 21 pieces from the game Monopoly.