Liz grew up with her siblings and mother; she lost her father as a child.
Donating her NerveEdit
Meredith ordered Heather Brooks to call Derek's sisters to ask them if they wanted to donate a nerve to fix Derek's hand. Liz was the one who agreed and she came over to Seattle. When she arrived, she told Meredith she wanted her to always be part of the family, and not only when she needed something. When it is realised that Callie and Jackson would have to take more nerve from Lizzie's calves for Derek's hand to regain function, Derek initially tells Lizzie that the operation is off. However after Meredith and Lizzie's discussion which leads to Lizzie pushing Derek towards the surgery, the operation goes ahead.After the operation, Meredith, wanting to show Lizzie her appreciation, visited Liz and showed her her ultrasound, revealing that she's pregnant. Lizzie was really happy that there would be a baby in the family.
Lizzie has several children, whom she mentioned when criticizing Meredith for not visiting or letting her family come to see Zola. Lizzie's children make up a portion of Derek's 5 nephews and 9 nieces.
Liz feels like her mother doesn't love her.
Lizzie was previously revealed to be a doctor like her three sisters and brother Derek, during their mother's (Carolyn Shepherd) visit to Seattle Grace where she said she gave birth to five doctors.