Annie Cooper was a patient at Grey Sloan Memorial Hospital who was in to be surgically separated from her identical twin sister, Liz Cooper.



As a child, everything she and her sister did was a show, to the point where they wondered what life would be like not to have an audience for everything.


Annie and Liz came into the hospital to be separated because Liz's heart was doing more work than Annie's, causing high output cardiac failure. For the surgery, Liz was designated Twin A and Annie Twin B, meaning that Liz was determined to be the stronger of the two. However, during the surgery, Liz developed a clot in her brain, switching their statuses. Derek Shepherd was unable to fix the damage caused by the clot and Liz was declared brain dead. After the surgery was completed, Annie made the difficult decision to withdraw care for Liz.


Annie is shyer and more reserved than her sister. She was more reluctant to be separated.




Annie and Liz's mother was opposed to separating them, saying it was too dangerous.

Liz CooperEdit

Annie has an identical twin sister, Liz. They were conjoined until health issues when they were adults forced them to be separated. Unfortunately, Liz didn’t survive the separation surgery.


Dr. KenzieEdit

Annie is very close with her childhood pediatrician, Dr. Kenzie, who accompanied her and her sister to the hospital for their surgery.

Notes and TriviaEdit

  • She was 25 at the time of her hospitalization.